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KMID : 0369820150450040341
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Jorunal of Korean Pharmaceutical Sciences
2015 Volume.45 No. 4 p.341 ~ p.347
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Sustained release coating of ibuprofen pellets at Wurster fluidization: statistical approach
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Sedighikamal Hossein
Zarghami Reza
Khadiv Parsi Parissa
Mostoufi Navid
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Abstract
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The Wurster fluidization coating is recognized in many pharmaceutical industries for its precise film coating onto particulate materials such as pellets, granules, and powders. The current work focused on some process variables to study sustained release behavior of ibuprofen pellets at a lab-scale Wurster fluidized bed coater. Applying design of experiment, the effect of mean pellets size (dp), air flow rate (Qa), coating solution flow rate (Qs), and drying time duration (td) were investigated statistically on the mean dissolution time (MDT) of ibuprofen pellets. Results in analysis of variance illustrated that a decrease in dp make rising of MDT due to decreasing the ibuprofen diffusivity in the media owing to trapping role of ethyl cellulose. It was also found increasing of Qs resulted in extending of MDT due as the coating solution deposited on the pellets surface was increased. While the td did not play an important role on the MDT, the MDT was increased by Qa because of pellets circulation within the bed.
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KEYWORD
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Sustained release, Wurster coater, Fluidized bed, Dissolution, Response surface, Pellet
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